Brain dopamine D4 receptors: basic and clinical status
نویسندگان
چکیده
منابع مشابه
Dopamine D4 receptors: curiouser and curiouser.
Identification of the D, receptor The D4 receptor was fit identified, using molecular biological techniques, from human’ and from rat2 and shown to be a member of the family of G protein-coupled dopamine receptors. It has substantial homology with Dz and DJ receptors (and is a member of the D,-like receptor subfamily) but its distribution and pharmacological properties are different from either...
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This article has no abstract
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Numerous data reported in lampreys, which belong to the phylogenetically oldest branch of vertebrates, show that the dopaminergic system was already well developed at the dawn of vertebrate evolution. The expression of dopamine in the lamprey brain is well conserved when compared to other vertebrates, and this is also true for the D2 receptor. Additionally, the key role of dopamine in the stria...
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Alterations of synaptic transmission have been considered a core feature of mental disorders; thus, we examined the role of dopamine D(4) receptors, which is highly implicated in attention-deficit hyperactivity disorder and schizophrenia, in regulating synaptic functions of prefrontal cortex, a brain region critical for cognitive and emotional processes. We found that D(4) stimulation caused a ...
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ژورنال
عنوان ژورنال: The International Journal of Neuropsychopharmacology
سال: 1999
ISSN: 1461-1457
DOI: 10.1017/s1461145799001352